The effect of antibiotic therapy on neonatal morbidity and mortality in multiple births

Preterm birth (PTB) remains a major cause of neonatal morbidity and mortality. The pathogenesis of the earliest preterm birth may be affected by bacterial intaurine infections but also still remain not fully elucidated. In high-income countries, it is standard practice to give antibiotics to women with pre-term, pre-labour rupture of membranes (pPROM) to delay birth and reduce the risk of infection. Contradictory findings in efficiency of therapeutic effects on antibiotic therapy will be provided by preliminary therapeutic studies. Multiple births are rarely being subjects of clinical and biodemographic studies. The main purpose of our retrospective study is to analyze the biodemographic mechanism of antibiotic therapy on neonatal vital health outcomes in multiple births with clinical birth registry data from a German University Hospital, collected in between 2006-2011. The data set with more over 581 multiple birth outcomes also provide individual and completely documented biodemographic information on the mothers and infants.